L’édoxaban diminue l’incidence des événements thrombo-emboliques asymptomatiques sur les phlébographies après ostéotomie tibiale de fermeture - 23/11/17
Edoxaban is effective in reducing the incidence of asymptomatic phlebographic events following closed-wedge high tibial osteotomy
, Y. Akamatsu, K. Kumagai, Y. Kusayama, H. Okuyama, K. Hirotomi, K. Shinohara, T. SaitoAbstract |
Introduction |
The purpose of this study was twofold: to investigate whether edoxaban significantly decreases the rate of venous thromboembolism (VTE) following closed-wedge high tibial osteotomy (CWHTO), in terms of phlebographic event, and to determine whether edoxaban is safe or increases the rate of hemorrhagic complications. We hypothesized that edoxaban would decrease the incidence of VTE and would not increase the rate of hemorrhagic complications.
Materials and methods |
We randomly enrolled 60 patients undergoing CWHTO. The patients were divided into two groups: one group receiving edoxaban (15mg in five patients, 30mg in 23patients) and a non-edoxaban group. All patients underwent computed tomography venography on day 7 to diagnose postoperative VTE. Blood samples were obtained on the day before CWHTO and on postoperative days 1, 3, 7 and 14. The incidence of VTE and hemorrhagic events in both groups was compared using unpaired Student t-test or chi-square test.
Results |
The incidence of VTE was significantly greater in the non-edoxaban group (31.3 % versus 7.1 %; P=0.02). The incidence of deep vein thrombosis (DVT) was also significantly greater in the non-edoxaban group (28.1 % versus 3.6 %; P=0.01). A single patient from the edoxaban group experienced major bleeding. On days 3 and 7, D-dimer levels were significantly lower in the edoxaban group (P=0.03 and 0.003, respectively). On days 3, 7 and 14, activated partial thromboplastin time was significantly greater in the edoxaban group (P=0.02, 0.01 and 0.006, respectively).
Conclusion |
Patients undergoing CWHTO are at risk of postoperative VTE. Edoxaban helps prevent asymptomatic phlebographic VTE and DVT following CWHTO; however, the risk of major bleeding must be considered.
Level of evidence |
II.
Le texte complet de cet article est disponible en PDF.Keywords : Closed-wedge high tibial osteotomy (CWHTO), Venous thromboembolism (VTE), Deep vein thrombosis (DVT), Pulmonary embolism (PE), Edoxaban
| ☆ | Cet article peut être consulté in extenso dans la version anglaise de la revue Orthopaedics & Traumatology: Surgery & Research sur Science Direct (sciencedirect.com) en utilisant le DOI ci-dessus. |
Vol 103 - N° 8
P. 869 - décembre 2017 Retour au numéro
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