Potential impact of the 4CMenB vaccine on oropharyngeal carriage of Neisseria meningitidis - 22/11/17
Highlights |
• | fHbp variants distribution looks rather different among carriers vs invasive strains. |
• | Potential impact of 4CMenB vaccine in carriers is due to the NHBA antigen. |
• | The potential impact might be observed particularly on encapsulated bacteria. |
• | Findings are depending of the type of strains circulating in carriers. |
Summary |
The analysis of the potential impact of the meningococcal vaccines in asymptomatic carriers has become one of the key aspects in the evaluation of new vaccines and of their impact on disease control. An important step in this direction is provided by the analysis of the sequence variability and surface-exposure of the 4CMenB (Bexsero®) vaccine antigens, as well as the cross-reactivity of vaccine induced antibodies, in isolates from healthy carriers. The Spanish Reference Laboratory, in collaboration with the University Hospital Marqués de Valdecilla in Santander (Spain), carried out a meningococcal carrier survey between May 2010 and April 2012 (population aged 4 to 19 years). The present study was done on 60 meningococcal carrier strains representative of the overall strain panel obtained and compared to invasive strains isolated in Spain in the same time. We found quantifiable levels of fHbp and NHBA expression and immunologic cross-reactivity in 10% and 75% of analyzed carrier strains, respectively, so the potential impact of the 4CMenB vaccine on Spanish asymptomatic carrier strains is expected to be mediated by the NHBA antigen.
Le texte complet de cet article est disponible en PDF.Keywords : MenB vaccine, Carrier strains, MATS, Potential coverage, Meningococcal strains
Plan
Vol 75 - N° 6
P. 511-520 - décembre 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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