The current study aimed at exploring hepatoprotective potential of Parrotiopsis jacquemontiana leaves methanol extract (PJM) in rat. PJM constituted of significant amount of total phenolic and total flavonoid content. PJM and ethyl acetate fraction (PJE) exhibited strong antioxidant potential (DPPH, hydroxyl ion, nitric oxide, iron chelating, β-carotene, reducing power and phosphomolybdate assay) in comparison to other extracts. CCl₄ toxicity displayed significant (p<0.05) increase in level of TBARS, H₂O₂, nitrite while a decrease in SOD, CAT, POD and GSH in liver samples of CCl₄ treated group. Serum analysis indicated significant increase in levels of ALT, AST and ALP and globulin whereas a decrease in albumin and total protein was also reported. In addition, levels of pro-inflammatory and fibrogenic cytokines (TNF-α, IL-6, TGF.β1, and leptin) of liver serum were elevated whereas adiponectin (anti-inflammatory cytokine) level was decreased in treated rats. CCl₄ induced DNA damage and histopathological architecture was also studied. However, co-administration with PJM in a dose-dependent manner reversed all the above pathological parameters caused by CCl₄ toxicity. HPLC-DAD analysis confirmed the existence of rutin, gallic acid, myricetin and caffeic acid in PJM and PJE while catechin was additionally present in PJM. Based on rich-antioxidant profile and hepatoprotective outcome on various pathological parameters prompted by CCl₄, it can be assumed to be a promising candidate shrub for phytomedicine development against various liver ailments and oxidative-stress related disorders.