Low radiation iridium 191m radionuclide angiography: Detection and quantitation of left-to-right shunts in infants - 12/10/17

Doi : 10.1016/S0022-3476(82)80119-4

S. Treves, M.D. ^⁎,^a,^b,^c,^d, Donald Fyler, M.D. ^a,^b,^c,^d, A. Fujii, M.D. ^a,^b,^c,^d, Alvin Kuruc, B.S. ^a,^b,^c,^d
^a Department of Radiology, The Children's Hospital Medical Center, Boston, Mass., USA
^b Department of Cardiology, The Children's Hospital Medical Center, Boston, Mass., USA
^c Department of Radiology, Harvard Medical School, Boston, Mass., USA
^d Department of Pediatrics, Harvard Medical School, Boston, Mass., USA

^*Reprint address: Division of Nuclear Medicine, Children's Hospital Medical Center, 300 Longwood Ave., Boston, MA 02115.

Abstract

Radionuclide angiography using iridium 191m was carried out in 34 premature infants and young children for detection and quantitation of left-to-right shunts. Ir-191m has a physical half-life of 4.96 seconds and can be imaged with conventional gamma scintillation cameras. The whole body radiation absorbed dose from Ir-191m is 3.5 mrad/mCi, which is about 40 times less radiation than with technetium 99m. Other advantages of Ir-191m include high photon flux for improved imaging and the possibility of multiple studies within a short period of time without background. Nine patients had simultaneous measurement of pulmonary-to-systemic flow ratio by Ir-191m angiography and oxymetry during cardiac catheterization; the correlation coefficient was 0.90. Radionuclide angiography with Ir-191m is a method with virtually no risk, rapid, accurate, and reproducible, and is ideally suited for the evaluation of left-to-right shunts in small children.

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†	Supported in part by grants from the Fannie Ripple Foundation and the National Institute of Health (2-P50-6M-18674-07), and by a contract from the U.S. Department of Energy (EY-76-S-4115).