Mycobacteria-specific cytokine responses as correlates of treatment response in active and latent tuberculosis - 06/10/17
Summary |
Objectives |
A biomarker indicating successful tuberculosis (TB) therapy would assist in determining appropriate length of treatment. This study aimed to determine changes in mycobacteria-specific antigen-induced cytokine biomarkers in patients receiving therapy for latent or active TB, to identify biomarkers potentially correlating with treatment success.
Methods |
A total of 33 adults with active TB and 36 with latent TB were followed longitudinally over therapy. Whole blood stimulation assays using mycobacteria-specific antigens (CFP-10, ESAT-6, PPD) were done on samples obtained at 0, 1, 3, 6 and 9 months. Cytokine responses (IFN-γ, IL-1ra, IL-2, IL-10, IL-13, IP-10, MIP-1β, and TNF-α) in supernatants were measured by Luminex xMAP immunoassay.
Results |
In active TB cases, median IL-1ra (with CFP-10 and with PPD stimulation), IP-10 (CFP-10, ESAT-6), MIP-1β (ESAT-6, PPD), and TNF-α (ESAT-6) responses declined significantly over the course of therapy. In latent TB cases, median IL-1ra (CFP-10, ESAT-6, PPD), IL-2 (CFP-10, ESAT-6), and IP-10 (CFP-10, ESAT-6) responses declined significantly.
Conclusions |
Mycobacteria-specific cytokine responses change significantly over the course of therapy, and their kinetics in active TB differ from those observed in latent TB. In particular, mycobacteria-specific IL-1ra responses are potential correlates of successful therapy in both active and latent TB.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Mycobacteria-specific cytokine responses change significantly over TB therapy. |
• | Mtb-specific IL-1ra responses decrease over therapy in active and latent TB. |
• | Mycobacteria-specific cytokine responses may be useful biomarkers of TB cure. |
Keywords : Tuberculosis, Cytokines, Biomarkers, Latent TB, Active TB, Monitoring
Plan
Vol 75 - N° 2
P. 132-145 - août 2017 Retour au numéro
Article précédent
- Diagnostic usefulness of Xpert MTB/RIF assay for detection of tuberculous meningitis using cerebrospinal fluid
- Syed Beenish Rufai, Amit Singh, Jitendra Singh, Parveen Kumar, Manimuthu Mani Sankar, Sarman Singh, TB Research Team 1 KumariNigamDivyaSharmaAnil KumarGuptaVivek SinghRawat, Kumari Nigam, Divya Sharma, Anil Kumar Gupta, Vivek Singh Rawat
- Clinical course and perinatal transmission of chronic hepatitis B during pregnancy: A real-world prospective cohort study
- Zhi-Xian Chen, Gui-Fang Gu, Zhao-Lian Bian, Wei-Hua Cai, Yi Shen, Yan-Li Hao, Sheng Zhang, Jian-Guo Shao, Gang Qin
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?