Association of a TNFSF13B (BAFF) regulatory region single nucleotide polymorphism with response to rituximab in antineutrophil cytoplasmic antibody–associated vasculitis - 27/09/17
Doi : 10.1016/j.jaci.2016.08.051
Federico Alberici, MD a, b, c 
, Rona M. Smith, MD a, Mariana Fonseca, PhD a, Lisa C. Willcocks, PhD a, Rachel B. Jones, MD a, Julia U. Holle, PhD d, Stefan Wieczorek, MD e, Thomas Neumann, PhD f, Davide Martorana, PhD g, Gina Gregorini, MD h, Renato A. Sinico, MD b, i, Annette Bruchfeld, PhD j, Iva Gunnarsson, PhD k, Sophie Ohlsson, PhD l, Bo Baslund, PhD m, Vladimir Tesar, PhD n, Zdenka Hruskova, PhD n, Maria C. Cid, PhD o, Augusto Vaglio, PhD p, Paul A. Lyons, PhD a, Kenneth G.C. Smith, PhD a, David R.W. Jayne, MD a
, Rona M. Smith, MD a, Mariana Fonseca, PhD a, Lisa C. Willcocks, PhD a, Rachel B. Jones, MD a, Julia U. Holle, PhD d, Stefan Wieczorek, MD e, Thomas Neumann, PhD f, Davide Martorana, PhD g, Gina Gregorini, MD h, Renato A. Sinico, MD b, i, Annette Bruchfeld, PhD j, Iva Gunnarsson, PhD k, Sophie Ohlsson, PhD l, Bo Baslund, PhD m, Vladimir Tesar, PhD n, Zdenka Hruskova, PhD n, Maria C. Cid, PhD o, Augusto Vaglio, PhD p, Paul A. Lyons, PhD a, Kenneth G.C. Smith, PhD a, David R.W. Jayne, MD a a Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
b Nephrology and Immunology Unit, ASST Santi Paolo e Carlo, San Carlo Borromeo Hospital, Milan, Italy
c Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
d Department of Rheumatology, Immunology and Vasculitis Clinic, Klinikum Bad Bramstedt, Bad Bramstedt, Germany
e Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany
f Department of Internal Medicine III, Jena University Hospital, Jena, Germany
g Medical Genetics Unit, University Hospital of Parma, Parma, Italy
h Department of Nephrology, A.O. Spedali Civili, Brescia, Italy
i Department of Medicine and Surgery, University of Milano-Bicocca (School of Medicine and Surgery), Monza, Italy
j Department of Renal Medicine, Karolinska University Hospital and Karolinska Institute, Solna, Sweden
k Department of Medicine, Unit of Rheumatology, Karolinska University Hospital, Karoliska Institute, Solna, Sweden
l Department of Nephrology and Transplantation, Skane University Hospital, Gothenburg, Sweden
m Department of Infectious Diseases and Rheumatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
n Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
o Vasculitis Research Unit, Department of Systemic Autoimmune Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain
p Nephrology Unit, University Hospital of Parma, Parma, Italy
| This study was supported by the National Institute of Health Research Cambridge Biomedical Research Centre (www.cambridge-brc.org.uk). F.A. has been supported by a European Renal Association-European Dialysis and Transplant Association long-term fellowship between September 2012 and September 2013. A.V. and D.M. were supported by the grant “A tailored approach to the immune monitoring and clinical management of viral and autoimmune diseases,” given by the Regione Emilia-Romagna within the Programma di Ricerca Regione-Università 2010–12. |
|
| Disclosure of potential conflict of interest: F. Alberici has received a grant from the European Renal Association-European Dialysis and Transplant Association, which has covered his salary for one year, and has received travel expenses from Amgen. R. M. Smith has received lecture fees from Roche. R. B. Jones has received consultancy fees from Chemocentryx and has previously undertaken an academic secondment to GlaxoSmithKline 2011-2013. S. Wieczorek's institution has received DFG grant “KFO170.” G. Gregorini has received consultancy fees from Roche Italy. R. A. Sinico has received payment for lectures from Roche Italy. A. Bruchfeld has received consultancy fees from Meck/MSD and Chemocentryx and payment for lectures from Roche and Genzyme. I. Gunnarsson is employed by Karolinska University. M.C. Cid received board membership from Roche and GSK; payment for lectures from Novartis and Boehringer-Inhelheim; and travel expenses from Roche. D. R. W. Jayne has received consultancy fees and payment for lectures from Roche and his institution has received grants and payment for lectures from Roche. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2016
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 139 - N° 5
P. 1684 - mai 2017 Retour au numéro
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