In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies - 27/09/17
, Ka He, MD, ScD b, ⁎ Abstract |
Background |
Studies of the associations between in utero 25-hydroxyvitamin D (25[OH]D) exposure and risk of childhood asthma, wheeze, and respiratory tract infections are inconsistent and inconclusive.
Objectives |
We sought to assess associations between 25(OH)D levels in cord blood or maternal venous blood and risk of offspring's asthma, wheeze, and respiratory tract infections.
Methods |
Data were derived from PubMed, Embase, Google Scholar, references from relevant articles, and de novo results from published studies until December 2015. A random-effects meta-analysis was conducted among 16 birth cohort studies.
Results |
Comparing the highest with the lowest category of 25(OH)D levels, the pooled odds ratios were 0.84 (95% CI, 0.70-1.01; P = .064) for asthma, 0.77 (95% CI, 0.58-1.03; P = .083) for wheeze, and 0.85 (95% CI, 0.66-1.09; P = .187) for respiratory tract infections. The observed inverse association for wheeze was more pronounced and became statistically significant in the studies that measured 25(OH)D levels in cord blood (0.43; 95% CI, 0.29-0.62; P < .001).
Conclusions |
Accumulated evidence generated from this meta-analysis suggests that increased in utero exposure to 25(OH)D is inversely associated with the risk of asthma and wheeze during childhood. These findings are in keeping with the results of 2 recently published randomized clinical trials of vitamin D supplementation during pregnancy.
Le texte complet de cet article est disponible en PDF.Key words : 25(OH)D, asthma, wheeze, respiratory tract infections, meta-analysis, birth cohort studies
Abbreviations used : 25(OH)D, NOS, OR, RR
Plan
| Supported by the Abbott Fund Institute of Nutrition Sciences (AFINS-2013-06); the Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai (11DZ2260-500); and the National Natural Science Foundation of China (81573140). |
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| Disclosure of potential conflict of interest: H. Feng and Y. Wan have received a grant from the Abbott Fund Institute of Nutrition Sciences (AFINS-2013-06). K. Pike has received a grant from the Food Standards Agency. H. Bisgaard has received grants from the Danish Ministry of Health, the Lundbeck Foundation, the Danish Strategic Research Foundation, the Danish Advanced Technology Foundation, and the National Institutes of Health (NIH) and has consultant arrangements with Chiesi Pharmaceuticals and Boehringer Ingelheim. W. Cai has received grants from Abbott Fund Institute of Nutrition Sciences (AFINS-2013-06) and the Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai (11DZ2260-500). K. He has received a grant from the NIH (R01ES021735). The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 139 - N° 5
P. 1508-1517 - mai 2017 Retour au numéro
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