Cardiorespiratory Fitness Change and Mortality Risk Among Black and White Patients: Henry Ford Exercise Testing (FIT) Project - 17/09/17
, Clinton A. Brawner, PhD a, Mouaz H. Al-Mallah, MD a, b, Waqas T. Qureshi, MD c, Michael J. Blaha, MD, MPH d, Steven J. Keteyian, PhD aAbstract |
Background |
Little is known about the relationship of change in cardiorespiratory fitness and mortality risk in Black patients. This study assessed change in cardiorespiratory fitness and its association with all-cause mortality risk in Black and White patients.
Methods |
This is a retrospective, longitudinal, observational cohort study of 13,345 patients (age = 55 ± 11 years; 39% women; 26% black) who completed 2 exercise tests, at least 12 months apart at Henry Ford Hospital, Detroit, Mich. All-cause mortality was identified through April 2013. Data were analyzed in 2015-2016 using Cox regression to calculate hazard ratios (HR) for risk of mortality associated with change in sex-specific cardiorespiratory fitness.
Results |
Mean time between the tests was 3.4 years (interquartile range 1.9-5.6 years). During 9.1 years (interquartile range 6.3-11.6 years) of follow-up, there were 1931 (14%) deaths (16.5% black, 13.7% white). For both races, change in fitness from Low to the Intermediate/High category resulted in a significant reduction of death risk (HR 0.65 [95% confidence interval (CI), 0.49-0.87] for Black; HR 0.41 [95% CI, 0.34-0.51] for White). Each 1-metabolic-equivalent-of-task increase was associated with a reduced mortality risk in black (HR 0.84 [95% CI, 0.81-0.89]) and white (HR 0.87 [95% CI, 0.82-0.86]) patients. There was no interaction by race.
Conclusions |
Among black and white patients, change in cardiorespiratory fitness from Low to Intermediate/High fitness was associated with a 35% and 59% lower risk of all-cause mortality, respectively.
Le texte complet de cet article est disponible en PDF.Keywords : Change, Longitudinal, Metabolic equivalent of task, METs, Retrospective
Plan
| Funding: None. |
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| Conflict of Interest: None. |
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| Authorship: The lead author had full access top all aspects of the research and writing process and takes full responsibility for this paper. All coauthors had access to the study data, have provided input on the statistical analysis, and have reviewed this manuscript. |
Vol 130 - N° 10
P. 1177-1183 - octobre 2017 Retour au numéro
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