High expression of PCBP2 is associated with progression and poor prognosis in patients with glioblastoma - 16/09/17
, Kai Zhuang ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 7 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Background |
Poly(C)‐binding protein 2 (PCBP2) has been found to have ambiguous functions in a variety of cancers. However, the specific biological function of PCBP2 and its mechanism in glioblastoma remain unclear. We investigated the expression of PCBP2 in 143 glioblastoma specimens to explore the linkage between PCBP2 expression and clinicopathological parameters as well as clinical significance. Furthermore, the underlying mechanisms of PCBP2 on glioblastoma progression were discussed in vitro.
Methods |
The transcriptional and translational levels of PCBP2 in 143 glioblastoma patients were detected by quantitative Real-time PCR (qRT-PCR) and western blot. The association of prognostic outcomes and PCBP2 expression was evaluated using Kaplan-Meier analysis.
Results |
PCBP2 expression was markedly increased in higher stages of glioblastoma compared with those in lower stages (P<0.001). High expression of PCBP2 was associated with higher clinical stage and histological grade (P<0.001). Further research suggested that PCBP2 upregulation was connected with poorer prognosis in patients with glioblastoma (P<0.001). Moreover, PCBP2 knockdown could significantly decreased the colony formation and invasion capability of glioblastoma cells (P<0.01). Conversely, PCBP2 overexpression could increase the colony formation and invasion capability (P<0.01).
Conclusion |
These findings indicated that PCBP2 might be a novel prognostic biomarker and a potential therapeutic target of glioblastoma.
Le texte complet de cet article est disponible en PDF.Abbreviations : PCBP2, MAVS, qRT-PCR
Keywords : Poly(C) binding protein 2 (PCBP2), Glioblastoma, Expression, Clinicopathologic parameters, Prognosis
Plan
Vol 94
P. 659-665 - octobre 2017 Retour au numéro
Article précédent
- Quercetin alleviates thermal and cold hyperalgesia in a rat neuropathic pain model by inhibiting Toll-like receptor signaling
- Chunmei Ji, Yongsheng Xu, Fang Han, Dehai Sun, Hanli Zhang, Xiumei Li, Xiaoyin Yao, Hong Wang
- β-asarone and levodopa coadministration increases striatal levels of dopamine and levodopa and improves behavioral competence in Parkinson's rat by enhancing dopa decarboxylase activity
- Liping Huang, Minzhen Deng, Sheng Zhang, Shiyao Lu, Xuehong Gui, Yongqi Fang
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?