Respiratory syncytial virus in adults with severe acute respiratory illness in a high HIV prevalence setting - 16/09/17

Doi : 10.1016/j.jinf.2017.06.007

Jocelyn Moyes ^a,^b,^⁎ , Sibongile Walaza ^a,^b, Marthi Pretorius ^c, Michelle Groome ^d, Anne von Gottberg ^a, Nicole Wolter ^a, Sumayya Haffejee ^e, Ebrahim Variava ^f,^g, Adam L. Cohen ^h, Stefano Tempia ^a,^i,^j, Kathleen Kahn ^k,^l,^m, Halima Dawood ⁿ, Marietjie Venter ^c, Cheryl Cohen ^a,^b, Shabir A. Madhi ^a,^d
for the
South African Severe Acute Respiratory Illness (SARI) Surveillance Group
^a Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa
^b School of Public Health, Health Sciences Faculty, University of the Witwatersrand, Johannesburg, South Africa
^c Department of Medical Virology, University of Pretoria, South Africa
^d Medical Research Council: Respiratory and Meningeal Pathogens Research Unit and Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa
^e National Health Laboratory Service, South Africa
^f Klerksdorp-Tshepong Hospital Complex, South Africa
^g The University of the Witwatersrand, South Africa
^h Strategic Information Group, Expanded Programme on Immunization, Department of Immunization, Vaccines and Biologicals, World Health Organization, Switzerland
ⁱ Influenza Program, Centers for Disease Control and Prevention, Pretoria, South Africa
^j Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA
^k MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
^l Centre for Global Health Research and Umeå University, Umeå, Sweden
^m INDEPTH Network Accra, Ghana
ⁿ Pietermaritzburg Hospital Complex and University of KwaZulu-Natal, Pietermaritzburg, South Africa

^∗Corresponding author. Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, Private Bag X4, Sandringham, 2131, Gauteng, South Africa. Fax: +27 11 882 9979.Centre for Respiratory Diseases and MeningitisNational Institute for Communicable DiseasesPrivate Bag X4SandringhamGauteng2131South Africa

Summary

Background

There are limited data on the epidemiology of respiratory syncytial virus (RSV) illness in HIV-infected adults or the elderly in Africa. We studied the epidemiology of RSV-associated severe acute respiratory illness (SARI) hospitalizations in adults in South Africa from 2009 through 2013.

Methods

Individuals admitted to sentinel surveillance hospitals were investigated by respiratory tract swabs for RSV, using a multiplex real-time polymerase chain reaction assay. The incidence of RSV-associated SARI was calculated for the one site with population denominators.

Results

Of 7796 participants investigated, 329 (4%) tested positive for RSV. On multivariable analysis, HIV-infected individuals with RSV-associated SARI had greater odds of being in the age groups 18–44 and 45–64 years (odd ratios (OR) 26.3; 95% confidence interval (CI) 6.2–112.1 and OR 11.4; 95% CI 2.6–50.0) compared with those ≥65 years and being female (OR 2.7; 95% CI 1.4–5.4). The relative risk of hospitalization with RSV-associated SARI was 12–18 times higher in HIV infected individual compared to that of HIV-uninfected.

Conclusion

The incidence of RSV-associated SARI was higher in HIV-infected individuals and those aged 65 years and older. Further studies are warranted to describe the disease association of RSV detected in adults with SARI.

Le texte complet de cet article est disponible en PDF.

Keywords : Respiratory syncytial virus, HIV, South Africa

Plan

Export

Vol 75 - N° 4

P. 346-355 - octobre 2017 Retour au numéro

Article précédent

CMV-specific T-cell immunity in solid organ transplant recipients at low risk of CMV infection. Chronology and applicability in preemptive therapy
Juan Damián Mena-Romo, Pilar Pérez Romero, Cecilia Martín-Gandul, Miguel Ángel Gentil, Gonzalo Suárez-Artacho, Ernesto Lage, Magdalena Sánchez, Elisa Cordero

| Article suivant

Returning ex-patriot Chinese to Guangdong, China, increase the risk for local transmission of Zika virus
Jiufeng Sun, De Wu, Haojie Zhong, Dawei Guan, Huan Zhang, Qiqi Tan, Huiqiong Zhou, Meng Zhang, Dan Ning, Baohuan Zhang, Changwen Ke, Tie Song, Jinyan Lin, Yonghui Zhang, Marion Koopmans, George F. Gao

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Respiratory syncytial virus in adults with severe acute respiratory illness in a high HIV prevalence setting - 16/09/17

Summary

Background

Methods

Results

Conclusion

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL