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Initiation of an Inhaled Corticosteroid During a Pediatric Emergency Visit for Asthma: A Randomized Clinical Trial - 29/08/17

Doi : 10.1016/j.annemergmed.2017.01.005 
Esther M. Sampayo, MD, MPH a, , Maryann Mazer-Amirshahi, PharmD, MD c, Elizabeth A. Camp, PhD a, Joseph J. Zorc, MD, MSCE b
a Baylor College of Medicine, Section of Emergency Medicine, Texas Children's Hospital, Houston, TX 
b Perelman School of Medicine at the University of Pennsylvania, Division of Emergency Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA 
c Department of Emergency Medicine, Georgetown University School of Medicine, MedStar Washington Hospital Center, Washington, DC 

Corresponding Author.

Abstract

Study objective

We determine whether prescribing an inhaled corticosteroid during a pediatric emergency department (ED) asthma visit increases ongoing use and improves outcomes.

Methods

This randomized trial enrolled children aged 1 to 18 years, with persistent asthma not previously prescribed a controller medication, and who were being discharged after ED asthma treatment. Intervention subjects received a 1-month prescription for an inhaled corticosteroid (fluticasone or budesonide by age) in addition to standard asthma therapy and instructions given to all patients. Outcomes included filling of the intervention and subsequent inhaled corticosteroid prescriptions, asthma-related symptoms and quality of life, and follow-up rates with a primary care provider. Outcomes were assessed during telephone interviews 2 and 8 weeks after the ED visit and by review of primary care provider and pharmacy records.

Results

One hundred forty-seven children were enrolled, and baseline measures were similar between groups. In the intervention group, 53.5% of patients filled an initial ED prescription for inhaled corticosteroid. There was no important difference between groups in subsequent filling of a primary care provider prescription (21% intervention versus 17% control; relative rate=1.24; 95% confidence interval 0.63 to 2.41). During the 2 weeks after the ED visit, intervention subjects reported reduced shortness of breath while awake and cough while asleep compared with controls. Groups did not differ by rates of primary care provider follow-up, functional limitations, or asthma-related symptoms and quality of life.

Conclusion

There was no difference in the proportion of patients who filled a primary care provider prescription after ED initiation of an inhaled corticosteroid. The intervention was associated with reduced reported symptoms but did not affect other asthma outcomes or primary care provider follow-up.

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Plan


 Please see page 332 for the Editor’s Capsule Summary of this article.
 Supervising editor: Kelly D. Young, MD, MS
 Author contributions: EMS conceptualized and designed the study, collected data, performed the initial analysis and interpretation of data, drafted the initial manuscript, and approved the final manuscript as submitted. MM-A collected data, revised the manuscript for important intellectual content, and approved the final manuscript as submitted. EC performed the statistical analysis, revised the manuscript for important intellectual content, and approved the final manuscript as submitted. JZ conceptualized and designed the study, interpreted the data, revised the manuscript for important intellectual content, and approved the final manuscript as submitted. EMS takes responsibility for the paper as a whole.
 All authors attest to meeting the four ICMJE.org authorship criteria: (1) Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; AND (2) Drafting the work or revising it critically for important intellectual content; AND (3) Final approval of the version to be published; AND (4) Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org/). The authors have stated that no such relationships exist.
 Trial registration number: NCT00294398
 A podcast for this article is available at www.annemergmed.com.


© 2017  American College of Emergency Physicians. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 70 - N° 3

P. 331-337 - septembre 2017 Retour au numéro
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