Flupirtine is used in many European countries for the treatment of different pain states because of its analgesic attributes. It is a centrally acting, non-opioid analgesic.

The aim of the study was to investigate an entire study the possibility of applying flupirtine (ktadolona) – selective neuronal potassium channel activators in the treatment of pharmacoresistant epilepsy and related non-psychotic depressive disorder in adults.

A total of 20 patients with the diagnosis of primary – generalized idiopathic epilepsy (IGE) and “non-psychotic depressive disorder due to epilepsy (F06.362)”. Before applying katadolon forte, patients received standard antiepileptic and antidepressant drugs (Depakine-Chrono 1000mg/day, 150mg lamotrigine/day, levitiratsetam 3000mg/day of citalopram 20mg/day). Assigning a first katadolon fote 14days 200mg 2 times a day, followed by 200mg three in day inside.

Of the 20 patients, 10 had no seizures, 8 marked decrease in the frequency of seizures in 2 patients therapy was not effective.

Our data should be considered preliminary, because small sample of patients and duration of follow-up (18months). The next phase of work will be carried out on a large sample of patients and a longer observation, placebo – controlled, double blind study.