It is known that several factors can influence the quality of life such as age, gender, socioeconomic status, the presence of mental illness or substance abuse.

Assess quality of life of outpatients observed in Young Adult Unit of our Psychiatry Department (Coimbra Hospital and University Centre – Portugal) and its relation with substance use.

Socio-demographic characterization of youth psychiatric outpatients observed during between 1st January 2015 and 31st July 2016. Portuguese versions of The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) and The World Health Organization Quality of Life scale (WHOQOL-BREF) were administered. A Spearman correlation coefficient between ASSIST and WHOQOL-BREF scores was calculated.

A total of 255 outpatients were observed: 64.3% females and 35.7% males; ages between 17 and 39 years old. ASSIST and WHOQOL-BREF were administered in 57 patients. Average ASSIST total score was 16.81 (median: 13.50), with tobacco and alcohol scoring higher. Average WHOQOL-BREF total was 13.74 (median: 13.67), with physical and psychological domains scoring less. We found a significant negative correlation between WHOQOL-BREF physical domain and ASSIST tobacco scores; and between WHOQOL-BREF social domain and ASSIST sedatives score.

Quality of life is influenced by several factors. Studies showed that consumers of psychoactive substances have lower WHOQOL-BREF scores than nonusers. In our sample, we did not find a significant correlation between global quality of life and different substances. This may be due to existence of low consumption of substances in the sample as well as the existence of other factors that might have influenced quality of life.