The effects of bariatric surgery on pharmacokinetics of antidepressants: A systematic review - 08/07/17
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Résumé |
Introduction |
Morbid obesity (BMI≥35) has been associated with mood and anxiety disorders. Regular use of antidepressants is common among patients who are candidate for bariatric surgery. The Roux-en-Y gastric bypass (RYGB) is one of the most common techniques used in bariatric surgery for reducing nutrient absorption. This type of surgery may however result in major changes in drug absorption.
Objectives and aims |
To report and discuss the consequences of bariatric surgery on changes in antidepressant drug absorption.
Methods |
We present all published in vitro and in vivo studies on antidepressant drug absorption after bariatric surgery.
Results |
In vitro studies showed that only bupropion had a significantly increased dissolution in a post-RYGB environment; venlafaxine and citalopram showed no alteration of dissolution; fluoxetine, paroxetine, sertraline, and amitryptiline had an significantly decreased dissolution in a post RYGB environment. Some in-vivo studies reported that only citalopram and escitalopram had an increased dissolution.
Conclusion |
After bariatric surgery, special caution is required in patients using antidepressant medication because of the expected changes in drug absorption, nutritional status, and electrolyte balance.
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Vol 41 - N° S
P. S232-S233 - avril 2017 Retour au numéro
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