Subtypes of psychosis among difficult-to-treat patients – A cluster analytical replication study among chronically psychotic, institutionalized dual diagnosis patients - 08/07/17
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Résumé |
Background |
Research is lacking on possible subtypes of psychosis in difficult-to-treat patients that require long-term institutionalisation due to a combination of psychosis, substance abuse and problem behaviours after multiple failed treatments.
Aim |
The aim of this study is to increase our knowledge of this group of patients in order to apply more targeted interventions.
Objective |
To identify subtypes of psychosis among this group by cluster analysis and compare these subtypes on different clinical variables.
Methods |
PANSS data was acquired for 117 patients. Separate clusters were identified by using Ward's method of hierarchical cluster analysis, replicating Dolffus et al., 1996 [1], who used this method in a cohort of schizophrenia patients. Subtypes of psychosis were identified using PANSS items. Clusters were compared on several clinical variables, f.e. course of admission.
Results |
Four distinct clusters were identified (Fig. 1): (1) a ‘positive cluster’, (2) a ‘mild cluster’, (3) a ‘negative cluster’, and (4) a ‘mixed group’. These clusters are similar to those found by Dolffus et al.
There was a significant association between cluster and co-morbid personality disorder, P<0.05. No significant association was found between clusters and other clinical variables.
Conclusions |
Among difficult-to-treat institutionalised patients four distinct subtypes of psychosis could be identified, comparable to those found in a cohort of schizophrenia patients.
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Vol 41 - N° S
P. S133-S134 - avril 2017 Retour au numéro
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