Eugenia uniflora fruit (red type) standardized extract: a potential pharmacological tool to diet-induced metabolic syndrome damage management - 01/07/17

Doi : 10.1016/j.biopha.2017.05.131

Pathise Souto Oliveira ^a,^{^{1
These authors equally contributed to this work.}}, Vitor Clasen Chaves ^b,^{^{1
These authors equally contributed to this work.}}, Natália Pontes Bona ^a, Mayara Sandrielly Pereira Soares ^c, Juliane de Souza Cardoso ^a, Flávia Aleixo Vasconcellos ^d, Rejane Giacomelli Tavares ^a, Marcia Vizzotto ^e, Luísa Mariano Cerqueira da Silva ^f, Fabiane Borelli Grecco ^f, Giovana Duzzo Gamaro ^c, Roselia Maria Spanevello ^c, Claiton Leoneti Lencina ^a, Flávio Henrique Reginatto ^b,^⁎ , Francieli Moro Stefanello ^a,^⁎
^a Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário s/n, Pelotas, RS, Brazil
^b Laboratório de Farmacognosia, Programa de Pós-Graduação em Biotecnologia e Biociências, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil
^c Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário s/n, Pelotas, RS, Brazil
^d Laboratório de Química Aplicada a Bioativos, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário s/n, Pelotas, RS, Brazil
^e Empresa Brasileira de Pesquisa Agropecuária, Centro de Pesquisa Agropecuária de Clima Temperado, Pelotas, RS, Brazil
^f Laboratório de Patologia Animal, Programa de Pós-Graduação em Veterinária, Universidade Federal de Pelotas, Campus Universitário s/n, Pelotas, RS, Brazil

^⁎Corresponding author at: Universidade Federal de Pelotas, Campus Universitário s/n, CEP 96160-000, Capão do Leão, RS, Brazil.Universidade Federal de Pelotas, Campus Universitário s/n, CEP 96160-000, Capão do Leão, RSBrazil^⁎⁎Corresponding author at: Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.Universidade Federal de Santa Catarina, Florianópolis, SCBrazil

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Abstract

The aim of this study was to investigate the effect of Eugenia uniflora fruit (red type) extract on metabolic status, as well as on neurochemical and behavioral parameters in an animal model of metabolic syndrome induced by a highly palatable diet (HPD). Rats were treated for 150days and divided into 4 experimental groups: standard chow (SC) and water orally, SC and E. uniflora extract (200mg/kg daily, p.o), HPD and water orally, HPD and extract. Our data showed that HPD caused glucose intolerance, increased visceral fat, weight gain, as well as serum glucose, triacylglycerol, total cholesterol and LDL cholesterol; however, E. uniflora prevented these alterations. The extract decreased lipid peroxidation and prevented the reduction of superoxide dismutase and catalase activities in the prefrontal cortex, hippocampus and striatum of animals submitted to HPD. We observed a HPD-induced reduction of thiol content in these cerebral structures. The extract prevented increased acetylcholinesterase activity in the prefrontal cortex caused by HPD and the increase in immobility time observed in the forced swim test. Regarding chemical composition, LC/MS analysis showed the presence of nine anthocyanins as the major compounds. In conclusion, E. uniflora extract showed benefits against metabolic alterations caused by HPD, as well as exhibited antioxidant and antidepressant-like effects.

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Keywords : Metabolic syndrome, Eugenia uniflora, Phenolic compounds, Pharmacological management

Plan

Introduction

Materials and methods

Phytochemicals

Animals and drug treatments

Body weight gain and food intake

Sample collection and biochemical assay

Behavioral analysis

Tissue preparation

Oxidative stress parameters

Acetylcholinesterase (AChE) activity

Statistical analysis

Results

Phytochemical characterization

Metabolic status

Behavioral parameters

Neurochemical parameters

Discussion

Conclusion

Conflict of interest

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Vol 92

P. 935-941 - août 2017 Retour au numéro

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Eugenia uniflora fruit (red type) standardized extract: a potential pharmacological tool to diet-induced metabolic syndrome damage management - 01/07/17

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