Induction of apoptosis in human colorectal cancer cell line, HCT-116 by a vanadium- Schiff base complex - 01/07/17
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 10 |
| Iconographies | 8 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Abstract |
Vanadium compounds are well known for their therapeutic interventions against several diseases. Various biochemical attributes of vanadium complexes inspired us to evaluate the cancer cell killing efficacy of the vanadium complex, viz., vanadyl N-(2-hydroxyacetophenone) glycinate [VO(NG)2]. Previously we showed that VO(NG)2 is an effective anticancer agent in in vitro and in vivo cancer models and imposed miniscule side effects. Herein we report that VO(NG)2 is significantly cytotoxic to various cancer cell lines. Furthermore, this redox active vanadyl complex altered the redox homeostatsis of many human cancer cell lines significantly. VO(NG)2 actuates programmed cell death in human colorectal carcinoma cells(HCT-116) through mitochondrial outer membrane permeabilization but in caspase independent manner, possibly by altering cellular redox status and by inflicting DNA damage. Thus, the present work is an attempt to provide many evidences regarding the potent and selective chemotherapeutic efficacy of the novel VO(NG)2.
Le texte complet de cet article est disponible en PDF.Keywords : Vanadium complex, Colorectal cancer, Redox imbalance, DNA damage, Apoptosis
Plan
Vol 92
P. 509-518 - août 2017 Retour au numéro
Article précédent
- A holistic review on the autoimmune disease vitiligo with emphasis on the causal factors
- Seema Patel, Abdur Rauf, Haroon Khan, Biswa Ranjan Meher, Syed Shams ul Hassan
- Lutein mitigates cyclophosphamide induced lung and liver injury via NF-κB/MAPK dependent mechanism
- Amal A. El-Kholy, Mohamed A. Elkablawy, Dina S. El-Agamy
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?