A holistic review on the autoimmune disease vitiligo with emphasis on the causal factors - 01/07/17
, Abdur Rauf b, ⁎ , Haroon Khan c, Biswa Ranjan Meher d, Syed Shams ul Hassan eBienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 8 |
| Iconographies | 2 |
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Highlights |
• | Vitiligo is an idiopathic systemic autoimmune disease affecting skin, hair and oral mucosa. |
• | Melanin loss cause psychological morbidity in the patients. |
• | Apart from thyroid disturbance, hormones like Corticotropin-releasing hormone, ACTH, MSH, melatonin, calcitriol, testosterone, estrogen), genes, and lifestyle choices (diet, cosmetic products) are causal of this disease. |
• | This review discusses these under-investigated facets of vitiligo onset and progression. |
Abstract |
Vitiligo is an idiopathic systemic autoimmune disease affecting skin, hair and oral mucosa. This genetic yet acquired disease characterized by melanin loss is a cause of morbidity across all races. Though thyroid disturbance has been recognized as a key trigger of this pathology, an array of other factors plays critical role in its manifestation. Multiple hormones (corticotropin-releasing hormone, adrenocorticotropic hormone, α-melanocyte-stimulating hormone, melatonin, calcitriol, testosterone, estrogen), genes (Human leukocyte antigen (HLA), Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), Forkhead box D3 (FOXD3), Cluster of differentiation 117 (CD117), Estrogen receptor (ESR) 1, Cyclooxygenase-2 (COX2), Vitiligo-associated protein 1 (VIT1)), and lifestyle choices (stress, diet, cosmetic products, and medications) have been suspected as drivers of this disorder. The pathological mechanisms have been understood in recent times, with the aid of genomic studies; however a universally-effective therapy is yet to be achieved. This review discusses these under-investigated facets of vitiligo onset and progression; hence, it is expected to enrich vitiligo research.
Le texte complet de cet article est disponible en PDF.Keywords : Vitiligo, Autoimmune disease, Melanin loss, Thyroid gland, Tyrosine
Plan
Vol 92
P. 501-508 - août 2017 Retour au numéro
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