Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549) - 01/07/17
, Ramalingam B. Subramanian a, Sampark S. Thakkar b, Arabinda Ray b, Vasudev R. Thakkar a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 10 |
| Iconographies | 7 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Abstract |
A number of drugs as well as lead molecules are isolated from natural sources. Phytol is one of such lead molecule belongs to terpenes group distributed widely in medicinal plants. In the present work, we investigated the cytotoxic behavior of phytol on human lung carcinoma cells (A549). Phytol was found to cause characteristic apoptotic morphological changes and generation of ROS in A549 cells. The mechanism of phytol involved the activation of TRAIL, FAS and TNF-α receptors along with caspase 9 and 3. In silico molecular docking studies revealed that phytol has a good binding affinity with glucose-6-phosphate dehydrogenase (G6PD), which is known to promote tumor proliferation. The ability of phytol to become potential drug candidate has been revealed from the pharmacokinetic study performed in the present study.
Le texte complet de cet article est disponible en PDF.Keywords : Phytol, ROS, G6PD, Apoptosis, TRAIL, Human lung carcinoma cells (A549)
Plan
Vol 92
P. 491-500 - août 2017 Retour au numéro
Article précédent
- Synthesis of platinum nanoparticles using seaweed Padina gymnospora and their catalytic activity as PVP/PtNPs nanocomposite towards biological applications
- V. Sri Ramkumar, A. Pugazhendhi, S. Prakash, N.K. Ahila, G. Vinoj, S. Selvam, G. Kumar, E. Kannapiran, R. Babu Rajendran
- A holistic review on the autoimmune disease vitiligo with emphasis on the causal factors
- Seema Patel, Abdur Rauf, Haroon Khan, Biswa Ranjan Meher, Syed Shams ul Hassan
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?