Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders - 08/06/17

Doi : 10.1016/j.biopha.2017.04.034

Martin Caprnda ^a,^{^{1
Co-first/equal authorship.}}, Peter Kubatka ^b,^c,^{^{1
Co-first/equal authorship.}}, Katarina Gazdikova ^d,^e,^⁎ , Iveta Gasparova ^f, Vanda Valentova ^b, Nadezda Stollarova ^g, Giampiero La Rocca ^h, Nazarii Kobyliak ⁱ, Jozef Dragasek ^j, Ioana Mozos ^k, Robert Prosecky ^l, Dario Siniscalco ^m, Dietrich Büsselberg ⁿ, Luis Rodrigo ^o, Peter Kruzliak ^p,^q,^⁎
^a 1st Department of Internal Medicine, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovakia
^b Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
^c Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
^d Department of Nutrition, Faculty of Nursing and Professional Health Studies, Slovak Medical University, Bratislava, Slovakia
^e Department of General Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia
^f Institute of Biology, Genetics and Medical Genetics, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovakia
^g Catholic University in Ružomberok, Faculty of Pedagogy, Department of Biology and Ecology, Ružomberok, Slovakia
^h Human Anatomy Section, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo and Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy
ⁱ Endocrinology Department, Bogomolets National Medical University, Kyiv, Ukraine
^j 1st Department of Psychiatry, Faculty of Medicine, Pavol Jozef Safarik University and University Hospital, Kosice, Slovakia
^k Department of Functional Sciences, Discipline of Pathophysiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania
^l Department of Internal Medicine, Merciful Brotherś Hospital, Brno, Czech Republic
^m Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy
ⁿ Weill Cornell Medical College in Qatar, Qatar Foundation − Education City, Doha, Qatar
^o University of Oviedo, Central University Hospital of Asturias (HUCA), Oviedo, Spain
^p Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
^q 2nd Department of Surgery, Faculty of Medicine,St. Annés University Hospital, Brno, Czech Republic

^⁎Corresponding author at: University of Veterinary and Pharmaceutical Sciences, Palackeho 1/1946, 612 42 Brno, Czech Republic.^⁎⁎Corresponding author at: Department of Nutrition, Faculty of Nursing and Professional Health Studies, Slovak Medical University, Limbova 12, 833 03 Bratislava, Slovakia.Department of NutritionFaculty of Nursing and Professional Health StudiesSlovak Medical UniversityBratislavaSlovakia

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Abstract

Stem cells have the capability of self-renewal and can differentiate into different cell types that might be used in regenerative medicine. Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) currently lack effective treatments. Although stem cell therapy is still on the way from bench to bedside, we consider that it might provide new hope for patients suffering with neurodegenerative diseases. In this article, we will give an overview of recent studies on the potential therapeutic use of mesenchymal stem cells (MSCs), neural stem cells (NSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and perinatal stem cells to neurodegenerative disorders and we will describe their immunomodulatory mechanisms of action in specific therapeutic modalities.

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Keywords : Stem cell therapy, Neurodegenerative disorders, Regenerative medicine

Plan

Introduction

Mesenchymal stem cells (MSCs)

Neural stem cells (NSCs)

Embryonic stem cells (ESCs)

Induced pluripotent stem cells (iPSCs)

Perinatal stem cells

Conclusions and future directions

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Vol 91

P. 60-69 - juillet 2017 Retour au numéro

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Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders - 08/06/17

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