Knockdown of PEBP4 suppresses proliferation, migration and invasion of human breast cancer cells - 04/05/17
, Fang Zhou b, 1, Zhen-yu Zhou a, Zhuang Hu a, Liang Chang a, Ming-de Ma aBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Phosphatidylethanolamine-binding protein 4 (PEBP4), a member of the PEBP family, plays a pivotal role in tumor progression. However, the roles of PEBP4 in breast cancer remain unclear. Therefore, in the present study, we investigated the effects of PEBP4 on breast cancer cell proliferation, migration and invasion, and the underlying mechanism was also explored. Our results showed that the expression of PEBP4 was significantly up-regulated in breast cancer cell lines. Knockdown of PEBP4 inhibited breast cancer cell proliferation in vitro and tumor growth in vivo. Furthermore, knockdown of PEBP4 suppressed breast cancer cell migration and invasion with prevented EMT. Mechanistically, knockdown of PEBP4 inhibited breast cancer cell proliferation and migration through the inactivation of PI3K/Akt signaling pathway. In conclusion, the present study demonstrated for the first time that knockdown of PEBP4 inhibited the proliferation, invasion and tumorigenesis in breast cancer cells. Thus, PEBP4 may serve as a potential therapeutic target for the treatment of breast cancer.
Le texte complet de cet article est disponible en PDF.Keywords : Breast cancer, PEBP4, Proliferation, Invasion, PI3K/Akt pathway
Plan
Vol 90
P. 659-664 - juin 2017 Retour au numéro
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