Chronic abdominal pain is a complex physical and psychological problem that requires comprehensive treatment options tailored to the needs of patients. Splanchnic nerve blocks and radiofrequency denervation of greater and lesser splanchnic nerves may provide prolonged treatment effect that still needs to be studied in a randomized prospective fashion. Here we describe improved fluoroscopy-guided technique for the radiofrequency ablation of splanchnic nerves, details on approach, technique, and potential complications.