The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies - 19/04/17
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Abstract |
Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is driven by both terminal keratinocyte differentiation defects and strong type 2 immune responses. In contrast to chronic plaque-type psoriasis, AD is now understood to be a much more heterogeneous disease, with additional activation of TH22, TH17/IL-23, and TH1 cytokine pathways depending on the subtype of the disease. In this review we discuss our current understanding of the AD immune map in both patients with early-onset and those with chronic disease. Clinical studies with broad and targeted therapeutics have helped to elucidate the contribution of various immune axes to the disease phenotype. Importantly, immune activation extends well beyond lesional AD because nonlesional skin and the blood component harbor AD-specific inflammatory changes. For this reason, future therapeutics will need to focus on a systemic treatment approach, especially in patients with moderate-to-severe disease.
Le texte complet de cet article est disponible en PDF.Key words : Atopic dermatitis, eczema, keratinocyte, immune, T helper cell, skin immune map, targeted therapy
Abbreviations used : AD, AMP, CRTH2, EASI, FLG, JAK, OX40L, PDE, TSLP
Plan
P.M.B. was supported in part by grant no. UL1TR001866 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) Program. |
Vol 139 - N° 4S
P. S65-S76 - avril 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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