Body fat mass distribution and interrupter resistance, fractional exhaled nitric oxide, and asthma at school-age - 19/04/17
Abstract |
Background |
Obesity and asthma often coexist. We hypothesized that detailed body fat distribution measures might be more strongly associated than body mass index (BMI) with childhood asthma.
Objective |
We examined the associations of total body and abdominal fat measures with respiratory resistance (Rint), fractional exhaled nitric oxide (Feno), and risks of wheezing and asthma in school-aged children.
Methods |
In a population-based prospective cohort study among 6178 children aged 6 years, we measured BMI, fat mass index, android/gynoid ratio, and preperitoneal and subcutaneous fat mass by physical examinations, dual-energy x-ray absorptiometry, and ultrasound, respectively. We performed Rint and Feno measurements, and assessed physician-diagnosed wheezing and asthma by questionnaires.
Results |
A higher BMI was associated with a higher Rint (Z score [95% CI], 0.06 [0.01-0.12]) and increased risk of wheezing (odds ratio [95% CI], 1.07 [1.00-1.14], per Z score BMI increase), but not with Feno or asthma. A high fat mass index was associated with a higher Rint (Z score [95% CI], 0.40 [0.13-0.68]). A high android/gynoid fat mass ratio was associated with a lower Feno (Sym% [95% CI], −9.8 [−16.3 to −3.4]), whereas a high preperitoneal fat mass was associated with a higher Feno (Sym% [95% CI], 6.5 [0.1-12.9]). Subcutaneous fat mass was not associated with any respiratory outcome.
Conclusions |
Studying detailed body fat distribution measures might provide better insight into the obesity-asthma paradigm.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Key words : Obesity, body composition, body fat mass distribution, Rint, fractional exhaled nitric oxide (Feno), wheezing, asthma
Abbreviations used : BMI, Feno, FVC, OR, Rint
Plan
| The Generation R Study is made possible by financial support from the Erasmus University Medical Center, Rotterdam, the Erasmus University Rotterdam, and The Netherlands Organization for Health Research and Development. V.J. received an additional grant from The Netherlands Organization for Health Research and Development (ZonMw-VIDI) and a European Research Council Consolidator Grant (grant no. ERC-2014-CoG-648916). L.D. received an additional grant from the Lung Foundation Netherlands (grant no. 3.2.12.089; 2012). The researchers are independent from the funders. The study sponsors had no role in the study design, data analysis, interpretation of data, or writing of this report. |
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| Disclosure of potential conflict of interest: L. Duijts has received research support from the Lung Foundation Netherlands (grant no. 3.2.12.089; 2012). The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 139 - N° 3
P. 810 - mars 2017 Retour au numéro
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