Correlation between early-life regulation of the immune system by microbiota and allergy development - 19/04/17
Abstract |
Early postnatal life is a key time for development of the immune system and colonization of the host by microbiota. Recent studies have shown that specific limbs of the immune system can be regulated by microbiota in a time-restricted period during early life. Studies in mouse models have shown that perturbations of the microbiota during early life can cause immune effects that can persist into adulthood and create increased host susceptibility to certain diseases. Here we discuss the role of early-life regulation of the immune system by the microbiota and how it can be related to allergy development.
Le texte complet de cet article est disponible en PDF.Key words : Allergy, microbiota, early-life, window of opportunity, neonate
Abbreviations used : GF, iNKT, SPF, Treg
Plan
| Supported by National Institutes of Health grant RO1 DK44319 and the Harvard Digestive Diseases Center (to R.S.B.) and Crohn's and Colitis Foundation of America grant no. 418509 (to T.G.). |
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| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
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| Terms in boldface and italics are defined in the glossary on page 1085. |
Vol 139 - N° 4
P. 1084-1091 - avril 2017 Retour au numéro
Article précédent
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