Loperamide Abuse Associated With Cardiac Dysrhythmia and Death - 19/04/17
, Kenneth H. Clark, MD b, Jeanna M. Marraffa, PharmD, DABAT cAbstract |
Loperamide is an over-the-counter antidiarrheal with μ-opioid agonist activity. Central nervous system opioid effects are not observed after therapeutic oral dosing because of poor bioavailability and minimal central nervous system penetration. However, central nervous system opioid effects do occur after supratherapeutic oral doses. Recently, oral loperamide abuse as an opioid substitute has been increasing among patients attempting to self-treat their opioid addiction. Ventricular dysrhythmias and prolongation of the QRS duration and QTc interval have been reported after oral loperamide abuse. We describe 2 fatalities in the setting of significantly elevated loperamide concentrations.
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| Supervising editor: Lewis S. Nelson, MD |
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| Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org/). The authors have stated that no such relationships exist. |
Vol 69 - N° 1
P. 83-86 - janvier 2017 Retour au numéro
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