Outcome disparities between African Americans and Caucasians in contemporary kidney transplant recipients - 18/04/17
, Leonard E. Egede b, Prabhakar K. Baliga aAbstract |
Background |
Racial disparities in African-American (AA) kidney transplant have persisted for nearly 40 years, with limited data available on the scope of this issue in the contemporary era of transplantation.
Methods |
Descriptive retrospective cohort study of US registry data including adult solitary kidney transplants between Jan 1, 2005 to Dec 31, 2009.
Results |
60,695 recipients were included; 41,426 Caucasians (68%) and 19,269 AAs (32%). At baseline, AAs were younger, had lower college graduation rates, were more likely to be receiving public health insurance and have diabetes. At one-year post-transplant, AAs had 62% higher risk of graft loss (RR 1.62, 95% CI 1.50–1.75) which increased to 93% at five years (RR 1.93, 95% CI 1.85–2.01). Adjusted risk of graft loss, accounting for baseline characteristics, was 60% higher in AAs (HR 1.61 [1.52–1.69]). AAs had significantly higher risk of acute rejection and delayed graft function.
Conclusion |
AAs continue to experience disproportionately high rates of graft loss within the contemporary era of transplant, which are related to a convergence of an array of socioeconomic and biologic risk factors.
Le texte complet de cet article est disponible en PDF.Keywords : African Americans, Kidney transplant, Graft loss, Acute rejection
Plan
Vol 213 - N° 4
P. 666-672 - avril 2017 Retour au numéro
Article précédent
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