Serum brain-derived neurotrophic factor and risk of atrial fibrillation - 18/04/17

Doi : 10.1016/j.ahj.2016.07.027

Faisal Rahman, BM, BCh ^a, Jayandra J. Himali, PhD ^b,^c,^d, Xiaoyan Yin, PhD ^b,^d,^e, Alexa S. Beiser, PhD ^b,^c,^d, Patrick T. Ellinor, MD, PhD ^f, Steven A. Lubitz, MD, MPH ^f, Ramachandran S. Vasan, MD ^b,^e,^g, Jared W. Magnani, MD, MSc ^h, David D. McManus, MD, ScM ^b,^i,^j, Sudha Seshadri, MD ^b,^c,^{^{1
These authors contributed equally to the manuscript.}}, Emelia J. Benjamin, MD, ScM ^b,^e,^g,^{^⁎,}^{^{1
These authors contributed equally to the manuscript.}}
^a Department of Medicine, Boston University Medical Center, Boston, MA
^b National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA
^c Department of Neurology, Boston University School of Medicine, Boston, MA
^d Department of Biostatistics, Boston University, Boston, MA
^e Section of Cardiovascular Medicine, Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA
^f Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA
^g Department of Epidemiology, Boston University School of Public Health, Boston, MA
^h Department of Medicine, Division of Cardiology, UPMC Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, PA
ⁱ Departments of Medicine and Quantitative Health Sciences, University of Massachusetts, Worcester, MA
^j Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA

^⁎Reprint requests: Emelia J. Benjamin, MD, ScM, Boston University Schools of Medicine and Public Health, Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702-5827.Boston University Schools of Medicine and Public Health, Framingham Heart Study73 Mt Wayte Ave, Suite 2FraminghamMA01702-5827

Background and objective

Brain-derived neurotrophic factor (BDNF) is expressed by endothelial cells and can affect cardiovascular function. We examined if serum BDNF was associated with risk of incident atrial fibrillation (AF) in the Framingham Heart Study.

Methods

We studied individuals without an AF diagnosis at baseline from the Framingham original and offspring cohorts. We used age- and sex-adjusted, and multivariable-adjusted Cox proportional hazards regression models to examine the association of serum BDNF concentrations with 10-year risk of incident AF.

Results

We studied 3,457 participants (mean age 65±11years, 58% women). During follow-up, 395 participants developed AF. In unadjusted analysis, higher mean serum BDNF concentration was associated with lower incidence of AF (hazard ratio 0.89 per SD, 95% CI 0.80-0.99). In multivariable-adjusted analyses, serum BDNF concentration was not significantly associated with incident AF (hazard ratio 0.98 per SD, 95% CI 0.88-1.09). Compared with the lowest quartile, BDNF levels in the other quartiles were not associated with risk of AF in multivariable-adjusted analyses. No interactions between sex or age with serum BDNF concentrations and risk of AF were found.

Conclusions

In our prospective, community-based sample, we did not find a statistically significant association of serum BDNF levels with risk of incident AF.

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Plan

Methods

Study sample

Clinical variables

Laboratory measurements of BDNF

Funding: This work was supported by contracts HHSN268201500001I and N01-HC-25195 (Vasan) and National Institutes of Health Grants R03AG045075 (Magnani); K23HL114724 (Lubitz); 6RO1NS17950 (Seshadri); 2R01HL092577 and 1R01HL128914 (Ellinor and Benjamin); R01HL101056 and 1P50HL120163 (Benjamin); R01HL104156 and K24HL105780 (Ellinor); and KL2RR031981, 5R01HL126911-02, 1R15HL121761-01A1, and 1UH2TR000921-02 (McManus). This work was also supported by Grant 2015084 from the Doris Duke Charitable Foundation (Magnani), Grant 2014105 from the Doris Duke Charitable Foundation (Lubitz), American Heart Association Award 13EIA14220013 (Ellinor), Evans Scholar Award from the Department of Medicine, Boston University School of Medicine (Vasan), and the Fondation Leducg 14CVD01 (Ellinor).

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Vol 183

P. 69-73 - janvier 2017 Retour au numéro

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Serum brain-derived neurotrophic factor and risk of atrial fibrillation - 18/04/17

Background and objective

Methods

Results

Conclusions

Plan

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