Respiratory Support for Very Low Birth Weight Infants Receiving Dexamethasone - 18/04/17
Abstract |
Objective |
To assess how neonatal intensive care units followed the American Academy of Pediatrics guidelines for use of dexamethasone in preterm infants by evaluating respiratory support at the time of dexamethasone administration.
Study design |
This is an observational study of infants discharged from one of 290 neonatal intensive care units from 2003 to 2010. The cohort included very low birth weight (<1500 g birth weight) infants born at ≤32 weeks gestational age. The main outcome was respiratory support at time of exposure to dexamethasone. Significant respiratory support was defined as invasive respiratory support (conventional or high-frequency ventilation) with a fraction of inspired oxygen (FiO2) > 0.3.
Results |
Of 81 292 infants; 7093 (9%) received dexamethasone. At the time that dexamethasone was initiated, 4604 (65%) of infants were on significant respiratory support.
Conclusions |
In accordance with the American Academy of Pediatrics recommendations, a majority of infants were on significant respiratory support when receiving dexamethasone, yet a substantial number of infants still received dexamethasone on less than significant respiratory support. Further research on reducing dexamethasone use in premature infants is required to decrease the risk of neurodevelopmental impairment.
Le texte complet de cet article est disponible en PDF.Keywords : dexamethasone, bronchopulmonary dysplasia, chronic lung disease, very low birth weight
Abbreviations : AAP, BPD, CMV, FiO2, HFV, NC, NCPAP
Plan
| Funding information is available at www.jpeds.com (Appendix). The design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript is solely the responsibility of the authors, and does not necessarily represent the official views of the funders. The authors declare no conflicts of interest. |
Vol 183
P. 26 - avril 2017 Retour au numéro
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