Local targeting NF-?B in the lung tissue of TB-infected mice diminishes the level of pathology - 18/04/17
Doi : 10.1016/j.tube.2016.12.001
Galena Shepelkova a, Vladimir Evstifeev a, Tatiana Kondratieva a, Irina Bocharova a, Mikhail Averbakh a, Alexander Apt a, b, ⁎ 
a Department of Immunology, Central Institute for Tuberculosis, Moscow, Russia
b Department of Immunology, School of Biology, Moscow State University, Russia
∗Corresponding author. Central Institute for Tuberculosis, Yauza alley, 2, Moscow, 107564, Russia.Central Institute for TuberculosisYauza alley, 2Moscow107564Russia
Abstract |
Mice of the genetically TB-susceptible strain I/St were infected with ∼100 CFU of Mycobacterium tuberculosis strain H37Rv, and after week 3 post-infection treated by inhalations of the NBD peptide selectively blocking NF-κB activation pathway. This therapy resulted in a pronounced attenuation of lung pathology and down-regulation of the expression of several genes encoding major inflammatory molecules, but did not diminish the level of mycobacterial multiplication in the lungs.
Le texte complet de cet article est disponible en PDF.Keywords : TB inflammation, NF-κB, NBD peptide, Lung pathology
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© 2016
Elsevier Ltd. Tous droits réservés.
Vol 103
P. 92-96 - mars 2017 Retour au numéro
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