Incidence and mortality of herpes simplex encephalitis in Denmark: A nationwide registry-based cohort study - 18/04/17
, Lars Skov Dalgaard a , Lars Jørgen Østergaard a , Mette Nørgaard b , Trine Hyrup Mogensen a, c Summary |
Objectives |
We aimed to investigate the incidence and mortality of herpes simplex encephalitis (HSE) in a nationwide cohort.
Methods |
From the Danish National Patient Registry, we identified all adults hospitalised with a first-time diagnosis of HSE in Denmark during 2004–2014. The HSE diagnoses were verified using medical records and microbiological data. Patients were followed for mortality through the Danish Civil Registry System. We estimated age-standardised incidence rates of HSE and 30-day, 60-day, and 1-year cumulative mortality. Furthermore, we assessed whether calendar year, age, gender, level of comorbidity, virus type, and department type was associated with HSE mortality.
Results |
We identified a total of 230 cases of HSE. Median age was 60.7 years (interquartile range: 49.3–71.6). The overall incidence rate was 4.64 cases per million population per year (95% confidence interval: 4.06–5.28). The cumulative mortality within 30 days, 60 days, and 1 year of the HSE admission was 8.3%, 11.3%, and 18.6%, respectively. Advanced age and presence of comorbidity were associated with increased 60-day and 1-year mortality.
Conclusions |
This nationwide study of verified HSE found a higher incidence than reported in previous nationwide studies. Presence of comorbidity was identified as a novel adverse prognostic factor. Mortality rates following HSE remain high.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The incidence of HSE was 4.64 cases per million population per year. |
• | The incidence was higher than reported by previous nationwide studies. |
• | Mortality rates following HSE remain high. |
• | Elderly and comorbid patients had remarkably higher mortality rates. |
Keywords : Herpes simplex virus, Herpes simplex encephalitis, Viral encephalitis, Epidemiology, Incidence, Mortality, Comorbidity, Prognosis
Plan
Vol 74 - N° 1
P. 42-49 - janvier 2017 Retour au numéro
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