Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors - 18/04/17
Summary |
Background |
Tuberculosis-diabetes co-morbidity (TB-DM) is characterized by increased inflammation with elevated circulating levels of inflammatory cytokines and other factors. Circulating angiogenic factors are intricately involved in the angiogenesis-inflammation nexus.
Methods |
To study the association of angiogenic factors with TB-DM, we examined the systemic levels of VEGF-A, VEGF-C, VEGF-D, VEGF-R1, VEGF-R2, VEGF-R3 in individuals with either TB-DM (n = 44) or TB alone (n = 44).
Results |
Circulating levels of VEGF-A, C, D, R1, R2 and R3 were significantly higher in TB-DM compared to TB individuals. Moreover, the levels of VEGF-A, C, R2 and/or R3 were significantly higher in TB-DM with bilateral or cavitary disease or with hemoptysis, suggesting an association with both disease severity and adverse clinical presentation. The levels of these factors also exhibited a significant positive relationship with bacterial burdens and HbA1c levels. In addition, VEGF-A, C and R2 levels were significantly higher (at 2 months of treatment) in culture positive compared to culture negative TB-DM individuals. Finally, the circulating levels of VEGF-A, C, D, R1, R2 and R3 were significantly reduced following successful chemotherapy at 6 months.
Conclusion |
Our data demonstrate that TB-DM is associated with heightened levels of circulating angiogenic factors, possibly reflecting both dysregulated angiogenesis and exaggerated inflammation.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Angiogenic factors are associated with disease severity and adverse clinical presentation in TB-DM. |
• | The systemic increase in angiogenic factor levels is driven by dysglycemia and bacterial burdens. |
• | Treatment results in reversal of enhanced levels of systemic angiogenic factors. |
Keywords : Tuberculosis, Diabetes, Angiogenesis, Biomarkers
Plan
Vol 74 - N° 1
P. 10-21 - janvier 2017 Retour au numéro
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