Doublecortin-like kinase 1 is a novel biomarker for prognosis and regulates growth and metastasis in basal-like breast cancer - 13/03/17

Doi : 10.1016/j.biopha.2017.01.082

Yuetao Lv ^a,^{^{1
Yuetao Lv and Ge Song are co-first authors.}}, Ge Song ^b,^{^{1
Yuetao Lv and Ge Song are co-first authors.}}, Rong Wang ^c, Linlin Di ^d, Jianling Wang ^a,^⁎
^a Department of Thyroid and Breast Surgery, Jining No.1 People’s Hospital, Jining 272011 Shandong, China
^b Intensive Care Unit, Jining No.1 People’s Hospital, Jining 272011 Shandong, China
^c Department of Oncology, Jining No.1 People’s Hospital, Jining 272011 Shandong, China
^d Electrocardiogram Room, Mental Disease Prevention and Treatment Institute, Jining 272051 Shandong, China

^⁎Corresponding author at: Department of Thyroid and Breast Surgery, Jining No.1 People’s Hospital, No.6 Jiankang Road, Jining 272011 Shandong, China.Department of Thyroid and Breast SurgeryJining No.1 People’s HospitalJiningShandong272011China

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Abstract

Doublecortin like kinase 1 (DCLK1) was observed overexpressed in several types of human cancers, and played a functional role in tumorigenicity, but little is known about the biological function of DCLK1 in basal-like breast cancer. In our results, the expressions of DCLK1 mRNA and protein were elevated in basal-like breast cancer tissues and cell lines. DCLK1 high-expression associated with clinical stage, lymph node metastasis, distant metastasis and histological grade. DCLK1 high-expression was an independent unfavorable prognostic factor for basal-like breast cancer patients. The biological experiments suggested knockdown of DCLK1 induced inhibition of basal-like breast cancer cells proliferation, migration and invasion. In conclusion, DCLK1 serves as a prognostic biomarker for basal-like breast cancer and a potential therapeutic target for basal-like breast cancer.

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Keywords : DCLK1, DCAMKL1, Biomarker, Breast cancer, Proliferation, Metastasis

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Vol 88

P. 1198-1205 - avril 2017 Retour au numéro

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Doublecortin-like kinase 1 is a novel biomarker for prognosis and regulates growth and metastasis in basal-like breast cancer - 13/03/17

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