Relationship between NR1I2 polymorphisms and inflammatory bowel disease risk: A systematic review and meta-analysis - 08/03/17
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 10 |
| Iconographies | 6 |
| Vidéos | 0 |
| Autres | 0 |
Summary |
Background and objective |
Inconsistent results regarding an association between polymorphisms within the Homo sapiens nuclear receptor subfamily 1 group I member 2 (NR1I2) gene and susceptibility to inflammatory bowel disease (IBD) have been reported. A systematic review and meta-analysis was thus undertaken to determine whether NR1I2 gene polymorphisms are associated with an increased risk of IBD.
Methods |
Article retrieval was performed using on-line databases, such as PubMed, Embase, CENTRAL, and WOS. After extracting eligible data, Mantel-Haenszel statistics were applied to calculate the odds radio (OR), 95% confidence interval (95% CI) and P value under a random or fixed-effects model.
Results |
A total of seven articles with 4410 IBD subjects and 4028 controls were included. Compared with the control group, no significant increase in IBD susceptibility was observed for the –25385C/T (OR=0.92, 95% CI=0.78∼1.07, P=0.259), –24381A/C (OR=0.96, 95% CI=0.87∼1.06, P=0.378), +8055C/T (OR=1.06, 95% CI=0.97∼1.15, P=0.186), or +7635A/G (OR=0.96, 95% CI=0.87∼1.05, P=0.348) polymorphisms within the NR1I2 gene under the allele model.
Conclusions |
Our meta-analysis failed to demonstrate an association between –25385C/T, –24381A/C, +8055C/T, or +7635A/G polymorphisms within the NR1I2 gene and overall IBD risk. A larger sample size is needed to validate our conclusion.
Le texte complet de cet article est disponible en PDF.Abbreviations : NR1I2, IBD, UC, CD, OR, CI, PPARα, FXR, NRAMP1, PXR, SNPs, WOS, HWE, LD, CYP3A4, PCR-RFLP
Plan
Vol 41 - N° 2
P. 230-239 - mars 2017 Retour au numéro
Article précédent
- Efficacy and safety of carbon dioxide insufflation versus air insufflation for endoscopic retrograde cholangiopancreatography: A meta-analysis update
- Wen You Zhang, Xue Pei Jiang, Lei Miao, Fei Chi Chen, Zhi Ming Huang, Xie Lin Huang
- Hepatitis B reactivation in a chronic hepatitis C patient treated with ledipasvir and sofosbuvir: A case report
- Pengcheng Ou, Zhixiong Fang, Jun Chen
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?