Role of the HTLV-1 viral factors in the induction of apoptosis - 03/01/17

Doi : 10.1016/j.biopha.2016.11.034

Mohammad Karimi ^a,^b,^d, Hamed Mohammadi ^a,^b, Maryam Hemmatzadeh ^a,^b, Asadollah Mohammadi ^c, Houshang Rafatpanah ^c,^⁎ , Behzad Baradaran ^a,^⁎
^a Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
^b Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
^c Inflammation and Inflammatory Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
^d Tabriz University of Medical Sciences, International Branch (Aras), Tabriz, Iran

^⁎Corresponding authors.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

pages	14
Iconographies	2
Vidéos	0
Autres	0

Abstract

Adult T-cell leukemia (ATL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) are the two main diseases that are caused by the HTLV-1 virus. One of the features of HTLV-1 infection is its resistance against programmed cell death, which maintains the survival of cells to oncogenic transformation and underlies the viruses’ therapeutic resistance. Two main genes by which the virus develops cancer are Tax and HBZ; playing an essential role in angiogenesis in regulating viral transcription and modulating multiple host factors as well as apoptosis pathways. Here we have reviewed by prior research how the apoptosis pathways are suppressed by the Tax and HBZ and new drugs which have been designed to deal with this suppression.

Le texte complet de cet article est disponible en PDF.

Keywords : HTLV-1, Apoptosis, Tax, HBZ