Anti-fatigue effect by active dipeptides of fermented porcine placenta through inhibiting the inflammatory and oxidative reactions - 03/01/17
, Hyun-Ja Jeong b, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 9 |
| Iconographies | 6 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Background |
Recently, we reported an anti-fatigue effect of fermented porcine placenta (FPP). Glycine-leucine (GL) and leucine-glycine (LG) dipeptides are main peptides of FPP. However, the therapeutic effects and underlying mechanisms of GL and LG dipeptides on fatigue are still unclear.
Methods |
Herein, we examined the anti-fatigue properties of GL and LG dipeptides using RAW264.7 macrophages and forced swimming test (FST) animal model.
Results |
Our data revealed that lipopolysaccharide (LPS)-induced interleukin (IL)-1β, tumor necrosis factor-α, and IL-6 productions were markedly inhibited by GL or LG in RAW264.7 macrophages without inducing cytotoxicity. LPS-enhanced nitric oxide (NO) production and inducible nitric oxide synthase expression were inhibited by GL or LG, whereas superoxide dismutase (SOD) activities were significantly enhanced by GL or LG in LPS-stimulated RAW264.7 macrophages. The present study also figured out that these effects of GL and LG were mediated by blockade of caspase-1 and nuclear factor-κB activation. In FST-induced fatigue mouse model, the mice which received the GL or LG for 21days showed significant decreases of IL-1β, IL-6, and NO serum levels. Treatment with GL or LG significantly enhanced levels of SOD and glycogen and significantly lowered levels of lactate dehydrogenase, aspartate transaminase, and alanine transaminase.
Conclusion |
Taken together, our results indicated that GL and LG dipeptides, active components of FPP, should be considered as candidate of anti-fatigue agents.
Le texte complet de cet article est disponible en PDF.Keywords : Glycine-leucine, Inflammatory cytokine, Superoxide dismutase, Nitric oxide, Forced swimming test
Plan
Vol 84
P. 51-59 - décembre 2016 Retour au numéro
Article précédent
- Sarcandra glabra combined with lycopene protect rats from lipopolysaccharide induced acute lung injury via reducing inflammatory response
- Tian-Yin Liu, Shi-Biao Chen
- Synthesis of stable nanosilver particles (AgNPs) by the proteins of seagrass Syringodium isoetifolium and its biomedicinal properties
- N.K. Ahila, V. Sri Ramkumar, S. Prakash, B. Manikandan, J. Ravindran, P.K. Dhanalakshmi, E. Kannapiran
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?