Evaluation of the miRNA profiling and effectiveness of the propolis on B-cell acute lymphoblastic leukemia cell line - 03/01/17
, Emin Karaca c, Asude Durmaz c, Burak Durmaz c, Ayca Aykut c, Husniye Kayalar d, Cigir Biray Avci b, Sunde Yilmaz Susluer b, Cumhur Gunduz b, Ozgur Cogulu cBienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 8 |
| Iconographies | 5 |
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Highlights |
• | Aydın propolis regulates expression levels of both oncogenic and tumor suppressor miRNAs. |
• | Aydın propolis induces apoptotic cell death in ALL cells.. |
• | Aydın propolis may be a promising epigenetic regulator in ALL treatment. |
Abstract |
Acute lymphoblastic leukemia (ALL) is one of the most frequent causes of death from cancer. Since the discovery of chemotherapeutic agents, ALL has become a model for improvement of survival. In parallel to this, serious side effects were observed and new natural therapeutic options has been discussed. One of these substances is called propolis which is a resinous substance gathered by honeybees. In the molecular era, miRNAs have been shown to play crucial roles in the development of many clinical conditions. The aim of this study is to evaluate the effect of Aydın propolis on 81 human miRNA activity in CCRF-SB leukemia cell line. Apoptotic effects of propolis on cell lines were also evaluated and apoptosis were found to be induced 1.5 fold in B-cell leukemia cells. The expression of 63 miRNAs (46 miRNAs were downregulated, 19 miRNAs were upregulated) in propolis treated leukemia cells have changed significantly (p<0.05).
In conclusion propolis has changed expression of miRNAs which have epigenetic effects on leukemic cells. It is thought that it can be a promising agent for ALL treatment for future studies.
Le texte complet de cet article est disponible en PDF.Keywords : Acute lymphoblastic leukemia, miRNA, Propolis, Apoptosis
Plan
Vol 84
P. 1266-1273 - décembre 2016 Retour au numéro
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