Ventilator-induced Lung Injury - 14/11/16
, Atul Malhotra, MD a, B. Taylor Thompson, MD bRésumé |
Prevention of ventilator-induced lung injury (VILI) can attenuate multiorgan failure and improve survival in at-risk patients. Clinically significant VILI occurs from volutrauma, barotrauma, atelectrauma, biotrauma, and shear strain. Differences in regional mechanics are important in VILI pathogenesis. Several interventions are available to protect against VILI. However, most patients at risk of lung injury do not develop VILI. VILI occurs most readily in patients with concomitant physiologic insults. VILI prevention strategies must balance risk of lung injury with untoward side effects from the preventive effort, and may be most effective when targeted to subsets of patients at increased risk.
Le texte complet de cet article est disponible en PDF.Keywords : Ventilator-induced lung injury, Acute lung injury, Acute respiratory distress syndrome, Mechanical ventilation, Respiratory mechanics
Plan
| Funding: All authors have received funding support from the National Institutes of Health (K24-HL132105; T32-HL007633; U01-HL123009). |
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| Conflicts of Interest: The authors have no potential conflicts of interest. |
Vol 37 - N° 4
P. 633-646 - décembre 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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