Treatment in carbon monoxide poisoning patients with headache: a prospective, multicenter, double-blind, controlled clinical trial - 02/11/16
, Erdal Tekin, MD b , Mustafa Basturk, MD c , Arif Duran, MD d , Mustafa Serinken, MD e , Mucahit Emet, MD b, ⁎ Abstract |
Background |
There is a lack of specificity of the analgesic agents used to treat headache and underlying acute carbon monoxide poisoning.
Objective |
To compare effectiveness of “oxygen alone” vs “metoclopramide plus oxygen” vs “metamizole plus oxygen” therapy in treating carbon monoxide–induced headache.
Design |
A prospective, multicenter, double-blind, controlled trial.
Setting |
Three emergency departments in Turkey.
Population |
Adult carbon monoxide poisoning patients with headache.
Methods |
A total of 117 carbon monoxide-intoxicated patients with headache were randomized into 3 groups and assessed at baseline, 30 minutes, 90 minutes, and 4 hours.
Main Outcome Measure |
The primary outcome was patient-reported improvement rates for headache. Secondary end points included nausea, need for rescue medication during treatment, and reduction in carboxyhemoglobin levels.
Results |
During observation, there was no statistical difference between drug type and visual analog scale score change at 30 minutes, 90 minutes, or 4 hours, for either headache or nausea. No rescue medication was needed during the study period. The reduction in carboxyhemoglobin levels did not differ among the 3 groups.
Conclusion |
The use of “oxygen alone” is as efficacious as “oxygen plus metoclopramide” or “oxygen plus metamizole sodium” in the treatment of carbon monoxide–induced headache.
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| ☆ | Conflict of interest statement: None. |
| ☆☆ | Financial support: None declared. |
Vol 34 - N° 11
P. 2140-2145 - novembre 2016 Retour au numéro
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