Low Serum Testosterone Level Predisposes to Artificial Urinary Sphincter Cuff Erosion - 28/10/16
Abstract |
Objective |
To examine the association between decreased serum testosterone levels and artificial urinary sphincter (AUS) cuff erosion.
Materials and Methods |
We evaluated serum testosterone levels in 53 consecutive patients. Low testosterone was defined as <280 ng/dL and found in 30/53 patients (56.6%). Chi-square and Student t tests, Kaplan-Meier analysis, binary logistic regression, and Cox regression analysis were used to determine statistical significance.
Results |
Nearly all men with AUS cuff erosions had low serum testosterone (18/20, 90.0%) compared to those without erosions (12/33, 36.4%, P < .001). Mean time to erosion was 1.70 years (0.83-6.86); mean follow-up was 2.76 years (0.34-7.92). Low testosterone had a hazard ratio of 7.15 for erosion in a Cox regression analysis (95% confidence interval 1.64-31.17, P = .009) and Kaplan-Meier analysis demonstrated decreased erosion-free follow-up (log-rank P = .002). Low testosterone was the sole independent risk factor for erosion in a multivariable model including coronary artery disease and radiation (odds ratio 15.78; 95% confidence interval 2.77-89.92, P = .002). Notably, history of prior AUS, radiation, androgen ablation therapy, or concomitant penile implant did not confound risk of cuff erosion in men with low testosterone levels.
Conclusion |
Men with low testosterone levels are at a significantly higher risk to experience AUS cuff erosion. Appropriate counseling before AUS implantation is warranted and it is unclear whether testosterone resupplementation will mitigate this risk.
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Financial Disclosure: Dr. Allen F. Morey receives honoraria for being a guest lecturer and meeting participant for American Medical Systems and Coloplast Corp. The remaining authors declare that they have no relevant financial interests. |
Vol 97
P. 245-249 - novembre 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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