MicroRNA-383 is a tumor suppressor and potential prognostic biomarker in human non-small cell lung caner - 21/10/16
, Youchao Jia a, Xiaofang Li a, Lei Zhang a, Ran Huo a, Jihong Yang b, Jia Feng a, Kun Ge c, Yongbin Yang d, Yan Zhang e, Jing Jiang fBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Purpose |
The purpose of this study is to examine the expression and clinical significance microRNA-383 (miR-383) in non-small cell lung cancer (NSCLC) both in vitro and in vivo.
Methods |
Tumorous miR-383 expressions were compared between NSCLC cell lines and normal lung cells. MiR-383 was upregulated in A549 and H596 cells to evaluate its tumor suppressive effect on NSCLC proliferation, invasion and migration in vitro. MiR-383 expression was also compared between 139-paired clinical NSCLC tissues and their adjacent non-carcinoma lung tissues, as well as between early-stage NSCLC tissues and advanced-stage NSCLC tissues. Correlation between tumorous miR-383 expression and NSCLC patients’ clinicopathological features and overall survival (OS) were also statistically analyzed.
Results |
MiR-383 was significantly downregulated in NSCLC cell lines. MiR-383 overexpression reduced proliferation, invasion and migration of A549 and H596 cells. In clinical samples, miR-383 was also found to be markedly downregulated in NSCLC carcinomas than in non-carcinoma lung tissues, and in advanced-stage carcinomas than in early-stage carcinomas. It was also found low tumorous miR-383 expression was significantly associated with NSCLC patients’ poor prognosis, including advanced TNM stages, positive lymph node metastasis, and shorter OS.
Conclusion |
Endogenous miR-383 is a functional tumor suppressor in NSCLC. It may also serve as an independent prognostic factor for patients with NSCLC.
Le texte complet de cet article est disponible en PDF.Keywords : NSCLC, MiR-383, Cancer proliferation, Cancer migration, Overall survival
Plan
Vol 83
P. 1175-1181 - octobre 2016 Retour au numéro
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