Nuclear and cytoplasmic features in the diagnosis of banal nevi, Spitz nevi, and melanoma - 15/10/16
Abstract |
Background |
Many authors have described cytologic features in a variety of melanocytic lesions but, to our knowledge, a statistical analysis of sensitivity, specificity, and overall accuracy of these features alone or in combination has not been performed.
Objective |
We sought to determine the diagnostic value of nuclear and cytoplasmic characteristics in the diagnosis of melanocytic lesions via multivariate statistical analysis.
Methods |
This is a retrospective observational study conducted on 300 melanocytic lesions. We evaluated a series of distinctive features; subsequently a multivariate model was used to determine sensitivity and specificity.
Results |
Major features that favor a diagnosis of melanoma include: pleomorphism with enlarged nuclei, mitotic figures, notching/corrugation of the nuclear envelope, and peppered moth nucleus. Features with intermediate value include: solid hyperchromasia, vesicular nucleus with single round nucleolus, and nuclear/cytoplasmic ratio greater than 4:1.
Limitations |
Limitations of this study include its retrospective nature, and the reliance on the original diagnostic classification of each neoplasm.
Conclusion |
Our data suggest that some nuclear alterations have greater value in the diagnosis of benign and malignant melanocytic lesions.
Le texte complet de cet article est disponible en PDF.Key words : banal nevi, chromatin, cytology, cytoplasm, melanoma, nucleus, Spitz nevus
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 75 - N° 5
P. 1032 - novembre 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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