Impact of glucose tolerance status on the development of coronary artery disease among working-age men - 04/10/16

Doi : 10.1016/j.diabet.2016.09.001

K. Fujihara ^a, R. Igarashi ^a, M. Yamamoto ^a, M. Ishizawa ^b, Y. Matsubayasi ^a, S. Matsunaga ^a, K. Kato ^a, C. Ito ^b, M. Koishi ^b, N. Yamanaka ^b, S. Kodama ^a, H. Sone ^a,^⁎
^a Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan
^b Japan Medical Data Center Co., Ltd., Tokyo, Japan

^⁎Corresponding author at: Niigata University Faculty of Medicine, Department of Internal Medicine, 1-754 Asahimachi, Niigata, Niigata 951-8510, Japan. Tel.: +81 25 368 9026; fax: +81 29 368 9300.Niigata University Faculty of Medicine, Department of Internal Medicine1-754 AsahimachiNiigataNiigata951-8510Japan

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Tuesday 04 October 2016

Abstract

Aims

To examine the impact of glucose tolerance status on the development of coronary artery disease (CAD) in working-age men in Japan.

Methods

This population-based retrospective cohort study included 111,621 men aged 31–60 years [63,558 with normal glucose tolerance (NGT); 37,126 with prediabetes; 10,937 with diabetes]. The Cox proportional-hazards regression model was used to identify variables related to the incidence of CAD.

Results

Multivariate analysis showed that, compared with NGT, diabetes increased the risk of CAD by 17.3 times (95% CI: 6.36–47.0) at ages 31–40 years, by 2.74 times (95% CI: 1.85–4.05) at ages 41–50 years and by 2.47 times (95% CI: 1.69–3.59) at ages 51–60 years. The HRs for CAD in men with diabetes aged 31–40 equaled that of men with NGT aged 51–60 [18.2 (7.15–46.4) and 19.4 (8.28–45.4), respectively].