Mutation spectra of RAS gene family in colorectal cancer - 24/08/16
Abstract |
Background |
The clinicopathologic features and frequency of KRAS mutations in colorectal cancer (CRC) patients have been reported; however, the characteristics and impact of NRAS and HRAS mutations on the survival of CRC patients have seldom been addressed.
Methods |
Under institutional review board approval, 1,519 CRC patients who underwent surgery were enrolled. Mutation status of RAS was determined by polymerase chain reaction and mass spectrophotometry.
Results |
The frequency of KRAS, NRAS, and HRAS mutations was 39.6%, 4.3%, and 1.7%, respectively. The KRAS mutation was associated with fewer left-sided tumors, fewer poor differentiated tumors, more mucin component, and less lymphovascular invasion. The NRAS or HRAS mutations were not associated with any of the clinicopathologic features examined. After univariate analysis, only NRAS mutation was associated with patients' overall and disease-free survival. However, the association of NRAS with patients' overall and disease-free survival disappeared after stepwise elimination.
Conclusions |
This study demonstrates the clinicopathologic characteristics of CRC patients with RAS mutations. Patients with NRAS mutation tended to have worse outcomes.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Of the 1,519 colorectal cancer patients, 602 (39.6%), 66 (4.3%), and 26 (1.7%) were found to have KRAS, NRAS, and HRAS mutations, respectively. |
• | The KRAS mutation was associated with fewer left-sided tumors, fewer poor differentiated tumors, more mucin component, and less lymphovascular invasion. |
• | Patients with the NRAS mutation, but not the KRAS or HRAS mutation, had an insignificantly worse outcome. |
Keywords : Colorectal cancer, KRAS, NRAS, HRAS, Survival
Plan
| The authors declare no conflicts of interest. |
Vol 212 - N° 3
P. 537 - septembre 2016 Retour au numéro
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