Hypolipidemic effect of dihydroisoquinoline oxaziridine in high-fat diet-fed rats - 08/08/16

Doi : 10.1016/j.biopha.2016.06.003

Rihab Aydi ^a,^{^{1
These authors contributed equally to this work.}}, Amel Ben Gara ^b,^{^{1
These authors contributed equally to this work.}}, Rim Chaaben ^d, Hajer Ben Saad ^e, Lotfi Fki ^b, Abdelfattah ElFeki ^c, Hafedh Belghith ^f, Karima Belghith ^b, Majed Kammoun ^a,^⁎
^a Laboratory of Chemistry of Natural Products, Faculty of Sciences, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia
^b Laboratory of plant biotechnology applied to crop improvement, Faculty of Sciences, University of Sfax, 802, 3018 Sfax, Tunisia,
^c Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, P.O. box 802, 3018 Sfax, Tunisia,
^d Biochemistry Laboratory, CHU Hédi Chaker, Sfax 3000, Tunisia
^e Pharmacology Laboratory, Faculty of Medicine, University of Sfax, 3000 Sfax, Tunisia
^f Laboratory of Biomass Valorization and Proteins Production in Eukaryotes, Center of Biotechnology of Sfax, University of Sfax, PB” 1177”, 3038 Sfax, Tunisia

^⁎Corresponding author.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

pages	9
Iconographies	9
Vidéos	0
Autres	0

Graphical abstract

Le texte complet de cet article est disponible en PDF.

Abstract

Obesity is a serious health problem that increases the risk of many complications, including diabetes and cardiovascular disease. This study aims to evaluate, for the first time, the effects of oxaziridine 3 on lipoprotein lipase activity in the serum of rats fed with a high-fat diet (HFD) on body weight, lipid profile and liver-kidney functions. The administration of oxaziridine 3 to HFD-rats lowered body weight and inhibited the lipase activity of obese rats leading to notable decrease of T-Ch, TGs and LDL-Ch levels accompanied with an increase in HDL-Ch concentration in serum. Moreover, the findings of this study revealed that oxaziridine 3 helped to protect liver tissue from the appearance of fatty cysts. Additionally, oxaziridine 3 administration to HFD-rats induces antioxidant activity proven by the increase of superoxide dismutase (SOD) and catalase (CAT) activities and the decrease in Thiobarbituric acid reactive substances (TBARS) levels. It also induces the protection of liver-kidney functions confirmed by a decrease in the levels of toxicity parameters in blood.

Le texte complet de cet article est disponible en PDF.

Keywords : Oxaziridine, Obesity, Liver-kidney functions

Plan

Export

Vol 82

P. 660-668 - août 2016 Retour au numéro

Article précédent

TCH1036, a indeno[1,2-c]quinoline derivative, potentially inhibited the growth of human brain malignant glioma (GBM) 8401 cells via suppression of the expression of Suv39h1 and PARP
Hsien-Feng Liao, Chien-Chin Lee, Pei-Chi Hsiao, Yi-Fong Chen, Chih-Hua Tseng, Cherng-Chyi Tzeng, Yeh-Long Chen, Jui-Chang Chen, Ya-Sian Chang, Jan-Gowth Chang

| Article suivant

Loss of Raf kinase inhibitor protein is associated with malignant progression in hepatic fibrosis
Quanfang Huang, Ling Wei, Chunhong Liang, Jinlan Nie, Shengjuan Lu, Chunyuan Lu, Shimei Tan, Shujuan Lv, Lang Zhuo, Zhongpeng Lu, Xing Lin

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Hypolipidemic effect of dihydroisoquinoline oxaziridine in high-fat diet-fed rats - 08/08/16

Graphical abstract

Abstract

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL