Clinical and virological profiling of sporadic hepatitis E virus infection in China - 08/08/16
, Hui Zhuang aSummary |
Objectives |
Recently, genotype 4 HEV (HEV-4) associated hepatitis E has overtaken HEV-1 infections in China, but few studies reported the clinical and virological features of HEV-4 infection.
Methods |
Sixty-two patients with acute hepatitis E (AHE) were enrolled from three hospitals in China. Clinical profiles and epidemiological records were analyzed. Patients' serum samples were tested for anti-HEV IgM/IgG and fecal samples were screened for HEV RNA. Representative HEV isolates were partially sequenced and analyzed phylogenetically.
Results |
A high median age (57.5 years) and an overwhelming proportion of males (51/62, 82%) were found. Most patients presented with symptoms of jaundice (56/62, 90%), malaise (44/62, 71%), anorexia (44/62, 71%) and nausea (41/62, 66%). Elevated mean values of total bilirubin (186 μmol/L), direct bilirubin (109 μmol/L), ALT (997 IU/L), AST (583 IU/L), ALP (159 IU/L) and GGT (170 IU/L) and reduced albumin level (32 g/L) were observed. The positive rate for anti-HEV IgM/IgG was 100% (62/62)/76% (47/62), for HEV RNA was 58% (25/43). Twelve HEV-4 isolates were obtained.
Conclusion |
All HEV isolates belonged to HEV-4 and showed high sequence similarity to swine HEV-4. Most of the sporadic cases had typical clinical symptoms, signs of AHE, and elevated levels of serum bilirubin and liver enzymes.
Le texte complet de cet article est disponible en PDF.Highlights |
• | A two-year prospective study of sporadic HEV infection in China. |
• | Sixty-two acute hepatitis E patients were included from 3 regions of China. |
• | Clinical symptoms and signs featured by jaundice and elevated liver enzymes level. |
• | A clear clustering of cases appeared in winter and patients were mostly older men. |
• | HEV isolated were genotypes 4a, 4d and 4h with high similarity to swine sequences. |
Keywords : Hepatitis E, Hepatitis E virus, Clinical features, Molecular epidemiology, Zoonotic transmission
Plan
Vol 73 - N° 3
P. 271-279 - septembre 2016 Retour au numéro
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