The burden of hospitalisation for varicella and herpes zoster in England from 2004 to 2013 - 08/08/16
, Julia Stowe a, Gayatri Amirthalingam a, Liz Miller a, Albert-Jan van Hoek a, bSummary |
Objectives |
We aimed to determine the hospital burden of varicella-zoster virus infection (VZV) in England during 2004–2013 to support a future cost-effectiveness analysis of a childhood varicella vaccination programme.
Methods |
We analysed the incidence, duration, outcome and costs of hospitalisations for VZV using the Hospital Episode Statistics (HES) database for the general and immunocompetent population. Mortality in HES was validated using data from the Office for National Statistics (ONS).
Results |
The average annual incidences of admissions due to varicella and herpes zoster were 7.6 (7.3–7.9) and 8.8 (8.6–9.0) per 100,000, respectively. The immunocompetent population accounted for 93% and 82% of the admissions due to varicella and herpes zoster, respectively. The average yearly number of hospital days was 10,748 (10,227–11,234) for varicella and 41,780 (40,257–43,287) for herpes zoster. The average yearly hospital costs (£2013/14) were £6.8 million (6.4–7.2) for varicella and £13.0 million (12.8–13.4) for herpes zoster. The average annual numbers of deaths identified in HES due to varicella and herpes zoster were 18.5 (14.3–22.8) and 160 (147–172), respectively. Comparison with ONS mortality data indicated a high level of uncertainty.
Conclusions |
Most of the hospital burden due to VZV-virus in England occurs in the immunocompetent population and is potentially vaccine-preventable.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The incidence of hospital admissions is very similar for varicella and herpes zoster. |
• | The average duration, costs and fatality rate are higher for hospitalisations due to herpes zoster than due to varicella. |
• | The majority of the VZV hospital burden is in the immunocompetent population and is potentially vaccine-preventable. |
• | The estimated VZV hospital burden is sensitive to the method used for case ascertainment. |
• | The uncertainty surrounding in-hospital mortality due to VZV is high. |
Keywords : Herpesvirus 3, Human, Chickenpox, Herpes zoster, Hospitalization, England, Incidence, Length of stay, Hospital costs, Hospital mortality
Plan
Vol 73 - N° 3
P. 241-253 - septembre 2016 Retour au numéro
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