Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis - 21/07/16
Doi : 10.1016/j.tube.2016.05.003
Michael G. Whitfield a, Elizabeth M. Streicher a, Tania Dolby b, John A. Simpson b, Samantha L. Sampson a, Paul D. Van Helden a, Annelies Van Rie c, d, e, Robin M. Warren a, ⁎, e 
a SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa
b National Health Laboratory Service, Cape Town, South Africa
c University of North Carolina at Chapel Hill, North Carolina, USA
d Epidemiology for Global Health Institute, Department of Epidemiology and Social Medicine, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
∗Corresponding author. SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical, TB Research Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, P.O. Box 241, Cape Town, 8000, South Africa. Tel.: +27 21 938 9073; fax: +27 21 938 9863.SA MRC Centre for Tuberculosis ResearchDST/NRF Centre of Excellence for BiomedicalTB Research Division of Molecular Biology and Human GeneticsFaculty of Medicine and Health SciencesStellenbosch UniversityP.O. Box 241Cape Town8000South Africa
Summary |
Pyrazinamide resistance is largely unknown in the spectrum of drug resistant phenotypes. We summarize data on PZA resistance in clinical isolates from South Africa. PZA DST should be performed when considering its inclusion in treatment of patients with rifampicin-resistant TB or MDR-TB.
Le texte complet de cet article est disponible en PDF.Keywords : Mycobacterium tuberculosis, Pyrazinamide, pncA gene, DNA sequencing
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© 2016
Elsevier Ltd. Tous droits réservés.
Vol 99
P. 128-130 - juillet 2016 Retour au numéro
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