Linkage and Genetic Association in Severe Asthma - 10/07/16

Doi : 10.1016/j.iac.2016.03.002

Bridgette L. Jones, MD, MSc ^a,^b,^⁎ , Lanny J. Rosenwasser, MD ^b
^a Division of Pediatric Pharmacology and Therapeutic Innovation, Department of Pediatrics, Children’s Mercy Hospitals and Clinics, University of Missouri Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA
^b Division of Allergy, Asthma and Clinical Immunology, Department of Pediatrics, Children’s Mercy Hospitals and Clinics, University of Missouri Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA

^∗Corresponding author. 2401 Gillham Road, Kansas City, MO 64108.2401 Gillham RoadKansas CityMO64108

Résumé

A significant body of work in the genetics of asthma currently exists. However, current knowledge has not been clarifying in understanding the pathophysiology of asthma and therapeutic treatment of the disease. Severe asthma in adults and children is a significant burden in relation to disproportionate disease morbidity, mortality, and health utilization. This disease phenotype is not well understood; current effective treatment regimens are limited. Genetic studies may lead to improved understanding of the pathophysiology of severe asthma and identification of relevant subsets, which allow more targeted and effective therapies and the realization of Precision Medicine in asthma.

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Keywords : Asthma, Genetics, Severe, GWAS, Linkage, Genotype, Endotype, Phenotype