False Positive Lyme Disease IgM Immunoblots in Children - 24/06/16
Doi : 10.1016/j.jpeds.2016.04.004
Paul M. Lantos, MD 1, Susan C. Lipsett, MD 2, Lise E. Nigrovic, MD, MPH 2, ⁎ 
1 Division of General Internal Medicine and Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC
2 Division of Emergency Medicine, Boston Children's Hospital, Boston, MA
∗Reprint requests: Lise E. Nigrovic, MD, MPH, Division of Emergency Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.Division of Emergency MedicineBoston Children's Hospital300 Longwood AveBostonMA02115
Abstract |
In our cross-sectional sample of 7289 serologic tests for Lyme disease, we identified 167 instances of a positive IgM immunoblot but a negative IgG immunoblot test result. Considering that only 71% (95% CI 64%-78%) of patients had Lyme disease, a positive IgM immunoblot alone should be interpreted with caution to avoid over-diagnosis of Lyme disease.
Le texte complet de cet article est disponible en PDF.Keywords : Lyme disease, immunoblots, pediatrics, diagnostic tests
Abbreviations : EIA, EM
Plan
| P.L. was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health (KL2 TR001115). L.N. was supported by the Harvard Catalyst Early Clinical Data Grant and Boston Children's Hospital (Research Faculty Council Pilot). The authors declare no conflicts of interest. |
© 2016
Elsevier Inc. Tous droits réservés.
Vol 174
P. 267 - juillet 2016 Retour au numéro
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